Review Article
The Role of Src Kinase in Macrophage-Mediated Inflammatory Responses
Table 1
Src family kinases and their functions in immune responses.
| Molecule | Distribution | Specific functions in immune responses | Reference |
| Src | Ubiquitous | - See Sections 2, 3, and 4 | | Fyn | Ubiquitous | - CD5 glycoprotein-mediated T-cell inhibition by inhibitory phosphorylation of Fyn |
[76] | - Rac and stress kinase activation in TCR signaling by Fyn | Yes | Ubiquitous | - LTB4-mediated degranulation of human neutrophils by Yes activation | [77] | Frk | Ubiquitous | - Unclear | | Blk | G, Mo, Ma, B | - Preferentially expression in B-cell lineage. Control of proliferation during B-cell development | [78] | Fgr | G, Mo, Ma | - Inhibition of Hck and Fgr kinase activity | [79] | - Inhibition of beta 2 integrin receptor and Syk kinase signaling by Fgr | [80] | Hck | G, Mo, Ma | - Inhibition of Hck and Fgr kinase activity | [79] | Lck | T, B | - Modulation of signaling and cellular fate of B-1 cells | [81] | | | - Promoting B-cell development | [82] | Lyn | P, G, Mo, Ma, B | - Redox sensor mediating initial neutrophil recruitment to wounds | [83] | | | - Inhibition of platelet aggregation with PECAM-1 | [84] |
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*Data from http://www.proteinkinase.de. G: granulocyte, Mo: monocyte, Ma: macrophage, B: B cell, T: T cell, and P: platelet.
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