Differential Expression of Sphingosine-1-Phosphate Receptors in Abdominal Aortic Aneurysms

<table>Quantitative analysis of S1P2 (upper panel) and 3 (lower panel) protein expression levels in western blot analysis. The relative S1P2 protein level was decreased by 73% (<svg height="11.375" id="M9" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 58.712502 11.375" width="58.712502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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t-10.5 -39.5l-43 -241q37 -13 83 -13q67 0 125.5 45t58.5 129z" id="x1D443"></path></g><g transform="matrix(.017,-0,0,-.017,15.582,11.112)"><path d="M512 -3l-437 233v51l437 233v-58l-378 -200v-2l378 -199v-58z" id="x3C"></path></g><g transform="matrix(.017,-0,0,-.017,30.286,11.112)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,38.446,11.112)"><use xlink:href="#x2E"></use></g><g transform="matrix(.017,-0,0,-.017,42.321,11.112)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,50.481,11.112)"><use xlink:href="#x35"></use></g>
</svg>) in AAAs (relative expression intensity of 0.29) compared with normal aortas (relative expression intensity of 1.08). S1PR3 protein levels were significantly upregulated in AAA tissues with average relative intensity of 0.65, whereas it was undetectable in normal aortas.</table>

Mediators of Inflammation

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Figure 2

Figure 2: Differential Expression of Sphingosine-1-Phosphate Receptors in Abdominal Aortic Aneurysms 