Increased Toll-Like Receptor 2 Expression in Peptidoglycan-Treated Blood Monocytes Is Associated with Insulin Resistance in Patients with Nondiabetic Rheumatoid Arthritis

Figure 3

Relationship between HOMA index and TLR2 or TLR4 expression (calculated as percentage of CD14⁺ monocytes expressing TLR2 or TLR4) in monocytes after stimulation with peptidoglycan or lipopolysaccharide in RA patients and normal controls (NC). (a) Positive correlation between HOMA index and TLR2 expression after stimulation with 10 μg/mL of peptidoglycan in RA patients (𝑟=0.514,𝑃=0.009); (b) no significant correlation between HOMA index and TLR2 expression in normal controls (𝑟=0.150,𝑃=0.682); (c) no significant correlation between HOMA index and TLR4 expression after stimulation with 10 ng/mL of lipopolysaccharide in RA patients (𝑟=0.230,𝑃=0.268).

(a)

(b)

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