High-Mobility Group Box-1 and Endothelial Cell Angiogenic Markers in the Vitreous from Patients with Proliferative Diabetic Retinopathy

Table 1

Comparisons of mean angiogenesis biomarker levels in proliferative diabetic retinopathy (PDR) and rhegmatogenous retinal detachment (RD) patients.

Disease group	HMGB1 (ng/mL)	VEGF (ng/mL)	sVE-cadherin (ng/mL)	sEng (ng/mL)
PDR (𝑛=36)	5.69 ± 8.5	0.85 ± 1.2	77.3 ± 63.5	3.64 ± 1.8
RD (𝑛=14)	1.70 ± 2.10	0.04 ± 0.1	10.7 ± 9.6	2.22 ± 0.7
P value (Mann-Whitney test)	0.008*	<0.001*	<0.001*	<0.003*

* Statistically significant at 5% level of significance.
HMGB1: high-mobility group box-1; VEGF: vascular endothelial growth factor; sVE-cadherin: soluble vascular endothelial-cadherin; sEng: soluble endoglin.