High-Mobility Group Box-1 and Endothelial Cell Angiogenic Markers in the Vitreous from Patients with Proliferative Diabetic Retinopathy

Table 2

Comparisons of mean angiogenesis biomarker levels in proliferative diabetic retinopathy (PDR) patients with or without active neovascularization.

Disease group	HMGB1 (ng/mL)	VEGF (ng/mL)	sVE-cadherin (ng/mL)	sEng (ng/mL)
Active PDR (𝑛=19)	7.28 ± 11.1	1.67 ± 1.4	75.8 ± 53.4	3.28 ± 1.9
Inactive PDR (𝑛=17)	4.02 ± 4.1	0.18 ± 0.4	78.8 ± 74.9	4.04 ± 1.6
RD (𝑛=21)	1.70 ± 2.1	0.04 ± 0.1	10.7 ± 9.6	2.22 ± 0.7
P value (ANOVA)	0.028*	<0.001*	<0.001*	0.006*

* Statistically significant at 5% level of significance.
HMGB1: high-mobility group box-1; VEGF: vascular endothelial growth factor; sVE-cadherin: soluble vascular endothelial-cadherin; sEng: soluble endoglin; RD: rhegmatogenous retinal detachment.