Superoxide Dismutase 3 Limits Collagen-Induced Arthritis in the Absence of Phagocyte Oxidative Burst
Figure 5
Peritonitis is limited by SOD3 in the absence of functional NOX2 complex. Similarly to wild-type mice, Ade-SOD3-treated Ncf1*/* mice had less peritoneal infiltrating macrophages than the Ade-LacZ-treated vector controls in the proteose peptone and IL-1β-induced peritonitis model (a). Normalized total cell numbers (b) show significant decrease in infiltrating macrophage population. Shown is pooled data from two independent experiments () (Nf = neutrophil, Mf = macrophage, Lc = lymphocyte).
