Review Article
Facts and Fiction: The Impact of Hypothermia on Molecular Mechanisms following Major Challenge
Table 1
Effects of hypothermia on apoptosis.
| Authors | Study design | Insult | Degree of hypothermia | Effects |
| Xu et al. [15] | In vitro study (mouse neurons) | Apoptosis using serum deprivation | 33°C | caspase-3/8/9 ↓, cytochrome-c ↓, JNK ↓ (no effect on bcl-2, bax) | Yang et al. [16] | In vitro study (HUVEC*) | Ischemia using oxygen-glucose deprivation | 33°C | caspase-3/8 ↓, bcl-2 ↑, bax ↓, JNK ↓ | Pastuszko et al. [17] | Experimental study (piglet neurons) | Ischemia | 33°C | caspase-3 ↓, bax ↓ (no effect on bcl-2) | Sahin et al. [18] | Experimental study (rat neurons) | Ischemia | 34°C | caspase-3/9 ↓, bcl-2 ↑, bax ↓ | Shuja et al. [19] | Experimental study (rat cardiac tissue) | Hemorrhage | 15°C | bcl-2 ↑ | Xiong et al. [20] | Experimental study (rat neurons) | Ischemia | 32-33°C | caspase-3 ↓, bcl-2 ↑ |
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*Human umbilical vein endothelial cells.
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