Facts and Fiction: The Impact of Hypothermia on Molecular Mechanisms following Major Challenge

Table 3

Effects of hypothermia on inflammatory cytokines.

Authors	Study design	Insult	Degree of hypothermia	Effects
Zheng et al. [21]	Experimental study (piglets)	Ischemia	18°C	TNF-α↓, IL-6 ↓
Sipos et al. [22]	Experimental study (pigs)	Ischemia	19/24/30°C	No effect TNF-α, IL-6, IL-10
Qing et al. [23]	Experimental study (pigs)	Ischemia	20/28°C	TNF-α↓, IL-10 ↑
Meybohm et al. [24]	Experimental study (pigs)	Ischemia	33°C	TNF-α↓, IL-1β↓, IL-6 ↓, IL-10 ↓
Su and Li [25]	Experimental study (pigs)	Ischemia	Not defined	TNF-α↓, IL-6 ↓
Lim et al. [26]	Experimental study (rats)	Inflammation	27°C	IL-1 β↓, IL-10 ↑
Fujimoto et al. [27]	Experimental study (rats)	Inflammation	32°C	IL-6 ↓, IL-10 ↑
Stewart et al. [28]	Experimental study (mice)	Inflammation	32°C	IL-6 ↑, IL-10 ↑; no effect on TNF-α, IL-1β
Kim et al. [29]	Experimental study (rats)	Hemorrhage	27–30°C	IL-6 ↓, IL-10 ↑
Gundersen et al. [30]	Experimental study (rats)	Hemorrhage	32.5–33°C	IL-6 ↓, no effect on TNF-α, IL-10
Beiser et al. [31]	Experimental study (mice)	Hemorrhage	33°C	IL-6 ↓
Wagner et al. [32]	Experimental study (mice)	Septic shock	27°C	IL-6 ↓
Vitarbo et al. [33]	Experimental study (rats)	Trauma (TBI)	33°C	TNF-α↓
Morita et al. [34]	Experimental study (rats)	Trauma (Lung)	34°C	TNF-α↓, IL-6 ↓, IL-10 ↑
Lee et al. [35]	Experimental study (rats)	Hypothermia (isolated)	30°C	IL-2 ↓, IL-10 ↑
Qayumi et al. [36]	Experimental study (pigs)	Lung transplantation	ex vivo preservation at 4°C	No effect on TNF-α, IL-2, IL-4, IL-10, Thromboxan
Shiozaki et al. [37]	Clinical study	Trauma (TBI)	34°C	No effect onTNF-α, IL-6, IL-10
Aibiki et al. [38]	Clinical study	Trauma (TBI)	32-33°C	IL-6 ↓