Facts and Fiction: The Impact of Hypothermia on Molecular Mechanisms following Major Challenge

Table 4

Effects of hypothermia on chemokines.

Authors	Study design	Insult	Degree of hypothermia	Effects
Dalen et al. [39]	In vitro study (human neurons)	Ischemia using oxygen-glucose deprivation	33°C	No effect on IL-8, MCP-1
Diestel et al. [40]	In vitro study (HUVEC*)	Inflammation	17/32°C	IL-8 ↓, MCP-1 ↓
Sutcliffe et al. [41]	In vitro study (HCEC**)	Inflammation	32°C	IL-8 ↓
Zheng et al. [21]	Experimental study (piglets)	Ischemia	18°C	IL-8 ↓
Li et al. [42]	Experimental study (rats)	Ischemia	32-33°C	MCP-1 ↓
Callaway et al. [43]	Experimental study (rats)	Ischemia	33°C	No effect on MCP-1 and MIP-1α
Hildebrand et al. [44]	Experimental study (mice)	Hemorrhage	27–30/30–33/33–35°C	MCP-1 ↓
Eggum et al. [45]	Clinical study	Surgery	25/32°C	RANTES and MCP-1↓
Menasche et al. [46]	Clinical study	Surgery	~26°C	No effect on IL-8

*human umbilical vein endothelial cells.
**human cerebral endothelial cells.