Facts and Fiction: The Impact of Hypothermia on Molecular Mechanisms following Major Challenge

Table 5

Effects of hypothermia on adhesion molecules.

Authors	Study design	Insult	Degree of hypothermia	Effects
Haddix et al. [47]	In vitro study (HUVEC*)	Inflammation	25°C	E-Selectin ↓
Sutcliffe et al. [41]	In vitro study (HCEC**)	Inflammation	32°C	No effect on ICAM-1, CD 18 (Integrin)
Frohlich et al. [48]	In vitro study (human leukocytes)	Inflammation	33/35°C	CD 11b (Mac-1) ↑, no effect on CD62L (L-Selectin)
Johnson et al. [49]	In vitro study (HUVEC*)	Hypothermia (isolated)	25°C	E-Selectin ↓
Meybohm et al. [24]	Experimental study (pigs)	Ischemia	33°C	ICAM-1 ↓
Callaway et al. [43]	Experimental study (rats)	Ischemia	33°C	No effect on ICAM-1
Wang et al. [50]	Experimental (rats)	Ischemia	33°C	ICAM-1 ↓
Deng et al. [51]	Experimental study (rats)	Ischemia/Inflammation	33°C	ICAM-1 ↓
Hanusch et al. [52]	Experimental study (rats)	Hypothermia (isolated)	Ex vivo storage after flushing lungs with cold fluid (4°C)	ICAM-1 ↓, VCAM-1 ↓, ELAM-1 ↓
Choi et al. [53]	Experimental study (rats)	Ischemia	33°C	ICAM-1 ↓
Menasche et al. [46]	Clinical study	Surgery	~26°C	No effect on P- und E-Selectin
Boldt et al. [54]	Clinical study	Surgery	27-28°C	No effect on ICAM-1, VCAM-1, ELAM-1

*human umbilical vein endothelial cells.
**human cerebral endothelial cells.