Pegylated Arginine Deiminase Downregulates Colitis in Murine Models

Table 2

WT mice: comparison of inflammatory markers in plasma and colonic explants in BALB/c (WT) mice treated with DSS and ADI-PEG versus sham controls. ^∗𝑃<0.05, ^∗∗𝑃<0.01, and  ^∗∗∗𝑃<0.001.

	Plasma			Colonic explant + LPS
Inflammatory markers	IL-6 (pg/mL)	SAA (μg/mL)	NO (μM)	IL-12p40 (pg/mL)
Control	45±14	12±1	24±1	550±25
ADI	27±5	48±37	27±2.5	650±50
DSS	182±27^∗	427+121^∗∗	36±3	875±150^∗
DSS + ADI-PEG (Low dose)	55±9	24+12^∗	24±3	475±50