Th17 Cell Enhances CD8 T-Cell Cytotoxicity via IL-21 Production in Emphysema Mice
Figure 8
IL-21 upregulates perforin and granzyme B expression and protein levels in CD8+ T cells. The purified CD8+ T cells were cultured in the presence of PHA (10 ng/mL) and rIL-21(50 ng/mL) or PHA (10 ng/mL) alone for 3 days and analyzed for (a) perforin and granzyme B expression in CD8+ T cells of air-exposed and CS-exposed mice (). (b) Perforin and granzyme B concentrations in CD8+ T cells of air-exposed and CS-exposed mice (). Significance was determined by independent-samples -test.
