Oleic Acid Induces Lung Injury in Mice through Activation of the ERK Pathway

Figure 2

Intratracheal administration of OA induces leukocyte activation and production of inflammatory mediators in the lung of Swiss Webster mice. Lipid body counting was done at 6 h (a) and 24 h (b), while LTB₄ measurements were done at 6 h (c) and 24 h (d). PGE₂ (e), IL-1β (f), IL-6 (g), TNFα (h), and MIP-1α (i) were all measured 24 h after the challenge. Control groups received sterile saline. Each bar represents the mean ± SEM of at least 6 animals. *𝑃<0.05, compared to controls.

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