Oleic Acid Induces Lung Injury in Mice through Activation of the ERK Pathway

Figure 6

Blocking ERK1/2 activation by treatment with U0126 decreases OA-induced lung inflammation. Treatment protocols are described in Methods. Neutrophils (a) and lipid body formation (b). The following cytokines were also measured: IL-6 (c) and IL-1β (d). Controls received the same volume of saline. All measurements were performed 24 h after OA challenge. Results are expressed as mean ± SEM from at least 6 animals. *𝑃<0.05 compared to control group; **𝑃<0.05 compared to OA stimulated group.

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