Anesthetic Isoflurane Posttreatment Attenuates Experimental Lung Injury by Inhibiting Inflammation and Apoptosis
Figure 1
Schematic diagram of the experimental design. The animals were randomly divided into four groups ( per group): ZY + vehicle, ZY + 1.4% ISO, sham + vehicle, and sham + 1.4% ISO. ISO treatment was performed in the ZY + 1.4% ISO and sham + 1.4% ISO groups, with the animals exposed to 1.4% ISO for 1 h starting at 1 and 6 h after ZY or NS injection, respectively. To serve as controls, animals in the sham + vehicle and ZY + vehicle groups were exposed to RA at the same time points. About 24 h after ZY or NS injection, ZY-induced lung damage was observed and assessed in mice. The survival rate was monitored 1, 2, 3, 5, 7, and 10 days after ZY or NS administration.
