Lipotoxicity: Effects of Dietary Saturated and Transfatty Acids

Figure 4

Schematic representation of SFA and TFA excess intake effects in endoplasmatic reticulum stress. BCL-2: B-cell lymphoma 2, CHOP: CCAAT/-enhancer-binding protein homologous protein, ER: endoplasmatic reticulum, GAAD 153: DNA damage-inducible gene 153, JNK: Jun N-terminal kinase, PERK: protein kinase RNA-like endoplasmic reticulum kinase, ROS: reactive oxygen species, SFA: saturated fatty acids, TFA: trans fatty acids, and TRAF2: TNF receptor-associated factor 2.