Genes Related to Mitochondrial Functions, Protein Degradation, and Chromatin Folding Are Differentially Expressed in Lymphomonocytes of Rett Syndrome Patients
Table 4
GO analysis of genes reported to be deregulated in PBMC of RTT patients.
Term
Description
value
Fold enrichment
Cluster 1
GO:0022900
Electron transport chain
9.01
GO:0006091
Generation of precursor metabolites and energy
5.06
GO:0045333
Cellular respiration
9.71
GO:0006120
Mitochondrial electron transport, NADH to ubiquinone
16.32
GO:0022904
Respiratory electron transport chain
12.04
GO:0006119
Oxidative phosphorylation
9.17
GO:0042775
Mitochondrial ATP synthesis coupled electron transport
12.99
GO:0042773
ATP synthesis coupled electron transport
12.99
GO:0015980
Energy derivation by oxidation of organic compounds
6.54
GO:0055114
Oxidation reduction
3.01
Cluster 2
GO:0006626
Protein targeting to mitochondrion
8.81
GO:0070585
Protein localization in mitochondrion
8.81
GO:0045039
Protein import into mitochondrial inner membrane
28.54
GO:0007007
Inner mitochondrial membrane organization
19.03
GO:0006839
Mitochondrial transport
4.96
Cluster 3
GO:0051436
Negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle
7.24
GO:0051444
Negative regulation of ubiquitin-protein ligase activity
7.03
GO:0051352
Negative regulation of ligase activity
7.03
GO:0051437
Positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle
6.92
GO:0051443
Positive regulation of ubiquitin-protein ligase activity
6.73
GO:0051439
Regulation of ubiquitin-protein ligase activity during mitotic cell cycle
6.63
GO:0051351
Positive regulation of ligase activity
6.45
GO:0051438
Regulation of ubiquitin-protein ligase activity
6.04
GO:0051340
Regulation of ligase activity
5.81
GO:0043086
Negative regulation of catalytic activity
2.78
GO:0044092
Negative regulation of molecular function
2.56
Cluster 4
GO:0031145
Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
7.24
GO:0010498
Proteasomal protein catabolic process
4.62
GO:0043161
Proteasomal ubiquitin-dependent protein catabolic process
4.62
Cluster 5
GO:0031397
Negative regulation of protein ubiquitination
6.36
GO:0031400
Negative regulation of protein modification process
4.68
GO:0031398
Positive regulation of protein ubiquitination
5.61
GO:0032269
Negative regulation of cellular protein metabolic process
3.58
GO:0031396
Regulation of protein ubiquitination
4.71
GO:0051248
Negative regulation of protein metabolic process
3.43
GO:0031401
Positive regulation of protein modification process