Anti-Inflammatory Effects of Ellagic Acid on Acute Lung Injury Induced by Acid in Mice
Figure 1
Ellagic acid prevents the development of airway inflammatory responses in the experimental model acid-initiated acute lung injury. Mice received ellagic acid (10 mg/kg, p.o.), dexamethasone (1 mg/kg, s.c.), or vehicle (water, p.o.) 30 minutes prior and/or after (24, 47, and/or 71 h) the acid intratracheal instillation into the left lung (see Methods). The kinetics of inflammation was determined at 12, 48, and 72 hours after acid-initiated acute lung injury. (a) Total cells, (b) neutrophils, (c) macrophages, and (d) lymphocytes were evaluated in the BALF. One group of animals received saline intratracheal instillation (control group). (e) Lung tissue inflammation was assessed by hematoxylin and eosin staining (H&E, original magnification, 200). Results represent the mean SEM of two or more independent experiments with three mice per group per experiment compared with control group; compared with HCl + vehicle group. Br: bronchus; V: venule.
