Anti-Inflammatory Effects of Ellagic Acid on Acute Lung Injury Induced by Acid in Mice

Figure 6

Ellagic acid (therapeutic treatment) dampens the exacerbation of inflammation induced by COX-2 inhibition in experimental model of acid-induced acute lung injury. Mice received ellagic acid (10 mg/kg, p.o.), dexamethasone (1 mg/kg, s.c.), or vehicle (water, p.o.) after (2, 24, and/or 47 h) the acid intratracheal instillation into the left lung. (a) Total leukocytes, (b) neutrophils, (c) macrophages, and (d) lymphocytes were evaluated in the BALF at 48 h after the acid instillation. Results represent the mean ± SEM of two or more independent experiments with three mice per group per experiment. ^∗𝑃<0.05 compared with control group;  ⁺𝑃<0.05 compared with HCl + vehicle group; ^#𝑃<0.05 compared with HCl + celecoxib group.

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