Systemic Immune Activation Leads to Neuroinflammation and Sickness Behavior in Mice

Figure 3

Peripheral LPS administration transiently increased cytokine levels in serum and brain. Comparison of selection of cytokines and one chemokine (MCP-1) in serum (left) and brain (right) after i.p. LPS administration. Dashed lines indicate the detection limit of measured cytokine. Note that serum concentrations are expressed in pg/mL, while brain levels are shown in pg/mg protein. Graphs are plotted as mean + SEM (𝑛=12 per group). Data were analyzed by ANOVA followed by independent samples t-test. *𝑃<0.05, **𝑃<0.01, ***𝑃<0.001 compared to 0 mg/kg LPS.

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