Neuropathic Pain in Animal Models of Nervous System Autoimmune Diseases

Table 2

Summary of pain symptoms observed in EAN models and potential therapeutic options for treating GBS pain.

EAN antigen	Animal model	Test site	Test	Symptoms during disease	Drug	Mode of action and effects of drug	References
200 𝜇g P2(57–81)	♂ Lewis rats	Forepaws & hindpaws	Hargreaves test	Thermal hyperalgesia (during disease course)			[115]
			Electronic von Frey	Mechanical allodynia (during disease course)
80 𝜇g P2(57–81)	♂ Lewis rats	Hindpaw	Electronic von Frey	Mechanical allodynia (before clinical signs, during disease, and after recovery)			[116]
80 𝜇g P2(53–78)	♂ Lewis rats	Hindpaw	Electronic von Frey	Mechanical allodynia (during disease)	Minocycline (an antibiotic of tetracycline family)	Inhibition of expression of MMPs and infiltration of immune cells to PNS; Significant decrease of disease severity; Attenuate mechanical allodynia in EAN rats	[117]
100 𝜇g P2(57–81)	♂ Lewis rats	Hindpaw	Electronic von Frey	Mechanical allodynia (before clinical signs and during disease)	Compound A (a plant-derived glucocorticoid receptor ligand)	A selective glucocorticoid receptor ligand with anti-inflammatory action; Attenuate neurological signs; Reduce mechanical allodynia in rats	[118]
200 𝜇g P2(57–81)	♂ Lewis rats	Hindpaw	Dynamic plantar aesthesiometer	Mechanical allodynia (during disease and recovery)	CD28 superagonist (CD28SupA)	Expands regulatory T-cell population; Ameliorate disease severity; Reduction of mechanical pain hypersensitivity in rats	[119]
25 𝜇g bovine peripheral myelin	♀ Lewis rats	Hindpaw	Dynamic plantar aesthesiometer	Mechanical allodynia (before clinical signs)			[120]