The Causative Pathogen Determines the Inflammatory Profile in Cerebrospinal Fluid and Outcome in Patients with Bacterial Meningitis
Table 3
CSF inflammatory parameters in control patients ().
Analytes
Samples under detection limit
Median (pg/mL) [min.–max.]
Dilution factor
Detection limit
IL-1β
5/7
n.d
1 : 1
0.19
IL-2
7/7
n.d.
1 : 1
0.38
IL-6
0/7
115 [95.06–175.1]
1 : 1
0.79
IL-10
1/7
39.96 [0.41–291.3]
1 : 1
0.41
IL-1RA
0/7
184.6 [99.82–2958]
1 : 1
10.76
TNF-α
4/7
n.d
1 : 1
0.22
IFN-γ
7/7
n.d
1 : 1
0.55
MCP-1
0/7
326 [116–11355]
1 : 5
0.63
MIP-1α
2/7
35.43 [1.23–536.6]
1 : 1
1.23
MIP-1β
4/7
n.d
1 : 1
27.65
TGF-α
0/7
24.16 [13.77–30.3]
1 : 1
0.69
MMP-9
0/7
106.8 [10.93–1153]
1 : 10
n.d.
A median value was calculated only when the majority of samples were above the limit of detection. Control samples were measured undiluted or diluted 1 : 5, respectively, 1 : 10.
1Detection limit as provided by the manufacturer.
