Table 4: Difference in CSF inflammatory parameters between patients with a nonfatal and a fatal outcome.
(a) Pooled pathogens

Nonfatal casesFatal casesMann-Whitney
Median (min.–max.) (pg/mL)Median (min.–max.) (pg/mL)

IL-1β13.19 (0.61–1040) 57.19 (9.84–682) 0.046
IL-21.6 (0.18–255.69)1.41 (0.38–6.9)0.6618
IL-6 67789 (3917–162002) 104035 (77100–175553) 0.0365
IL-1015764 (509.5–217931)14131 (809–90755)0.9351s
IL-1RA 117918 (3183–1.301 × ) 337610 (19362–983243) 0.0209
TNF-α195.1 (17.6–3390) 484.3 (88.41–1199) 0.0436
IFN-γ11.16 (0.42–1920)49.13 (1.77–2853)0.1823
MCP-12101 (309.8–40005)2903 (1187–20728)0.2193
MIP-1α935.6 (133.8–27027)1166 (30.75–16122)0.9351
MIP-1β2728 (530.7–24661)3555 (1263–90852)0.4177
TGF-α41.05 (10.30–305.2) 93.3 (36.74–302.3) 0.0099
MMP-9463489 (1877–5.319 × 106)1.258 × 106 (313541–4.497 × 106)0.0671
WBC4600 (100–186000)11100 (1000–42400)0.062
Nitrite/nitrate*137.5 (23.15–625)226.9 (83.6–368.5)0.3627

(b) SP only

Non-fatal cases ( )Fatal cases ( )Mann-Whitney
Median (min.–max.) (pg/mL)Median (min.–max.) (pg/mL)

IL-1β54.44 (1.79–1040)206.9 (9.84–682)0.5253
IL-27.87 (0.38–19.81)1.6 (0.38–5.55)0.1452
IL-6106232 (4440–150456)136215 (77100–175553)0.3434
IL-107515 (509.5–44609)7497 (809–17392)0.6010
IL-1RA55240 (4413–275000)121576 (19362–983243)0.1591
TNF-α70.65 (0.22–570.9) 416.2 (88.41–1199) 0.048
IFN-γ40.82 (8.03–1920)190.7 (23.73–2853)0.202
MCP-110109 (1691–23059)2897 (2020–20307)0.8207
MIP-1α829.1 (256.9–3828)416.4 (30.75–1738)0.5025
MIP-1β2732 (575.8–6685)3771 (1263–7342)0.6313
TGF-α35.52 (16.36–153.5)100.5 (36.74–302.3)0.149
MMP-91.103 × 106 (275632–4.254 × 106)2.676 × 106 (475112–4.497 × 106)0.2331
WBC4600 (100–64000)12930 (3200–42400)0.1375

(c) NM only

Non-fatal cases ( )Fatal cases ( )Mann-Whitney
Median (min.–max.) (pg/mL)Median (min.–max.) (pg/mL)

IL-1β10.56 (0.61–325.9)50.5 (10.48–205.4)0.3056
IL-21.41 (0.38–25.69)1.22 (0.38–6.9)0.916
IL-667789 (5917–162002)1100160 (77742–145357)0.3056
IL-1016715 (1883–217931)47476 (5436–90755)0.1974
IL-1RA 182057 (3183–305690) 447933 (275000–639929) 0.001
TNF-α267.2 (17.6–3390)552.4 (247.4–1126)0.2661
IFN-γ9.1 (2.62–219.8)8.3 (1.77–102.7)0.5413
MCP-11283 (309.8–40005)2909 (1187–20728)0.3056
MIP-1α1200 (133.8–27027)1937 (585.1–16122)0.444
MIP-1β3137 (530.7–24661)3388 (1851–90852)0.5528
TGF-α44.05 (10.3–146.5)86.05 (58.93–144.7)0.0526
MMP-9585934 (1877–5.319 × 106)525821 (313541–2.188 × 106)0.7996
WBC4900 (100–17000)7800 (1000–38560)0.3983

Significantly higher CSF concentrations in patients with a fatal outcome are represented in italic lines.