Glucagon-Like Peptide-1 Triggers Protective Pathways in Pancreatic Beta-Cells Exposed to Glycated Serum
Figure 1
GLP-1 abrogates AGE-induced intracellular ROS production. After treatment for 5 days in standard medium (CTR) or in medium containing AGEs (GS) in the presence or absence of 10 nmol/L GLP-1, HIT-T15 cells were prelabeled with DCFH-DA for 30 min and fluorescence was analyzed. Data were expressed as the mean ± SE of four independent experiments. and versus CTR; versus GS.