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Mediators of Inflammation
Volume 2013 (2013), Article ID 321460, 11 pages
Research Article

Sildenafil (Viagra) Protective Effects on Neuroinflammation: The Role of iNOS/NO System in an Inflammatory Demyelination Model

1Departamento de Histologia e Embriologia, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Rua Monteiro Lobato 255, 13083-862 Campinas, SP, Brazil
2Laboratório de Ultraestrutura, Centro de Pesquisas Aggeu Magalhães, Fundação Oswaldo Cruz, Av. Professor Moraes Rego, s/n, Cidade Universitária, 50670-420 Recife, PE, Brazil

Received 27 March 2013; Revised 12 June 2013; Accepted 13 June 2013

Academic Editor: Geeta Ramesh

Copyright © 2013 Catarina Raposo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [9 citations]

The following is the list of published articles that have cited the current article.

  • Catarina Rapôso, Rayana Leal de Almeida Luna, Ana Karolina Santana Nunes, Rodolfo Thomé, and Christina Alves Peixoto, “Role of iNOS-NO-cGMP signaling in modulation of inflammatory and myelination processes,” Brain Research Bulletin, 2014. View at Publisher · View at Google Scholar
  • Jelle Praet, Caroline Guglielmetti, Zwi Berneman, Annemie Van der Linden, and Peter Ponsaerts, “Cellular and molecular neuropathology of the cuprizone mouse model: clinical relevance for multiple sclerosis,” Neuroscience & Biobehavioral Reviews, 2014. View at Publisher · View at Google Scholar
  • Mohamed H. Zahran, Abdelaziz M. Hussein, Nashwa Barakat, Amira Awadalla, Shery Khater, Ahmed Harraz, and Ahmed A. Shokeir, “Sildenafil activates antioxidant and antiapoptotic genes and inhibits proinflammatory cytokine genes in a rat model of renal ischemia/reperfusion injury,” International Urology and Nephrology, 2015. View at Publisher · View at Google Scholar
  • Ana Karolina Santana Nunes, Catarina Rapôso, Sura Wanessa Santos Rocha, Karla Patrícia de Sousa Barbosa, Rayana Leal de Almeida Luna, Maria Alice da Cruz-Höfling, and Christina Alves Peixoto, “Involvement of AMPK, IKβα-NFκB and eNOS in the sildenafil anti-inflammatory mechanism in a demyelination model,” Brain Research, 2015. View at Publisher · View at Google Scholar
  • Christina Alves Peixoto, and Fabiana Oliveira dos Santos Gomes, “The role of phosphodiesterase-5 inhibitors in prostatic inflammation: a review,” Journal of Inflammation, vol. 12, no. 1, 2015. View at Publisher · View at Google Scholar
  • R.L. Luna, A.K.S. Nunes, A.G.V. Oliveira, S.M.R. Araujo, A.J.J.M. Lemos, S.W.S. Rocha, B.A. Croy, and C. Peixoto, “Sildenafil (Viagra®) blocks inflammatory injury in LPS-induced mouse abortion: a potential prophylactic treatment against acute pregnancy loss?,” Placenta, 2015. View at Publisher · View at Google Scholar
  • Mariana Aragão Matos Donato, Edlene Lima Ribeiro, Dilênia de Oliveira Cipriano Torres, Amanda Karolina Soares e Silva, Fabiana Oliveira dos Santos Gomes, Bruna Santos e Silva, Sura Wanessa Santos Rocha, and Christina Alves Peixoto, “Chronic treatment with Sildenafil has no effect on folliculogenesis or fertility in C57BL/6 and C57BL/6 knockout for iNOS mice,” Tissue and Cell, 2015. View at Publisher · View at Google Scholar
  • Puebla Cassini-Vieira, Fernanda Assis Araújo, Filipi Leles da Costa Dias, Remo Castro Russo, Silvia Passos Andrade, Mauro Martins Teixeira, and Luciola Silva Barcelos, “iNOS Activity Modulates Inflammation, Angiogenesis, and Tissue Fibrosis in Polyether-Polyurethane Synthetic Implants,” Mediators of Inflammation, vol. 2015, pp. 1–9, 2015. View at Publisher · View at Google Scholar
  • Murat Yarim, M. Onder Karayigit, Ayhan Gacar, Yonca B. Kabak, M. Yavuz Gulbahar, Tolga Guvenc, and Mahmut Sozmen, “Inducible nitric oxide synthase expression in cerebellum of dogs naturally infected with canine distemper virus,” Ankara Universitesi Veteriner Fakultesi Dergisi, vol. 62, no. 3, pp. 189–196, 2015. View at Publisher · View at Google Scholar