Sildenafil (Viagra) Protective Effects on Neuroinflammation: The Role of iNOS/NO System in an Inflammatory Demyelination Model
Figure 2
Immunofluorescence for GFAP. (a) and (d) show expression and physiological locations of GFAP in mice without iNOS and without treatment. CPZ administration ((b), (e)) induced reactive gliosis, with thicker and more numerous astrocytic processes, compared to control. GFAP remained high in relation to control, after application of sildenafil plus CPZ ((c), (f)). Arrows show astrocytic processes and arrowheads point to processes around vessels and other cells. W: white matter, M: molecular layer, P: purkinje layer, G: granular layer, and v: vessel. Bars: 20 μm.
