Palmitoylethanolamide Is a Disease-Modifying Agent in Peripheral Neuropathy: Pain Relief and Neuroprotection Share a PPAR-Alpha-Mediated Mechanism
Figure 6
Oedema evaluation. On the 14th day after CCI, 5 μm nerve sections of formalin-fixed tissues were analyzed by Azan-Mallory stain and the presence of oedema infiltrate was evaluated and quantified by an arbitrary scale starting from 1, mild oedema, up to 10, widespread oedema. Effect of PEA repeated treatments (30 mg kg−1 s.c. daily) was observed in (a) PPAR- and in (b) mice where the distal and proximal tract of the ipsilateral ligated nerve of CCI was compared with the contralateral and with the sciatic nerve of sham-operated animals. Quantitative analysis was performed evaluating 5 animals for each group. was considered as significantly different from sham, vehicle-treated mice. was considered as significantly different from CCI, vehicle-treated mice.
