Palmitoylethanolamide Is a Disease-Modifying Agent in Peripheral Neuropathy: Pain Relief and Neuroprotection Share a PPAR-Alpha-Mediated Mechanism

<table>Light micrographs from 5 <i>μ</i>m transverse sections of mouse sciatic nerve stained by Azan-Mallory, comparison between PPAR-<svg height="16.85" id="M41" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 29.275 16.85" width="29.275" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,16.588)"><path d="M545 106q-67 -118 -134 -118q-24 0 -40 37.5t-30 129.5h-2q-47 -72 -103 -119.5t-108 -47.5q-47 0 -76 45.5t-29 119.5q0 113 85 204t174 91q47 0 70 -33.5t43 -119.5h3q32 47 80 140l55 13l10 -9q-47 -80 -138 -201q17 -99 27.5 -136t22.5 -37q23 0 69 61zM333 204
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</svg> and PPAR-<svg height="16.85" id="M42" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 29.275 16.85" width="29.275" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,16.588)"><path d="M545 106q-67 -118 -134 -118q-24 0 -40 37.5t-30 129.5h-2q-47 -72 -103 -119.5t-108 -47.5q-47 0 -76 45.5t-29 119.5q0 113 85 204t174 91q47 0 70 -33.5t43 -119.5h3q32 47 80 140l55 13l10 -9q-47 -80 -138 -201q17 -99 27.5 -136t22.5 -37q23 0 69 61zM333 204
q-14 98 -31 149.5t-50 51.5q-49 0 -94 -70t-45 -164q0 -55 15.5 -86t40.5 -31q70 0 164 150z" id="x1D6FC"></path></g>
<g transform="matrix(.012,-0,0,-.012,9.712,8.425)"><path d="M535 230h-483v50h483v-50z" id="x2212"></path></g><g transform="matrix(.012,-0,0,-.012,16.697,8.425)"><path d="M368 703l-264 -866h-60l265 866h59z" id="x2F"></path></g><g transform="matrix(.012,-0,0,-.012,21.599,8.425)"><path d="M535 230h-483v50h483v-50z" id="x2212"></path></g>
</svg>  animals; 14th day. Sham: section of sciatic nerve from sham animals; CCI + vehicle: distal part of the sciatic nerve of injured vehicle-treated animals; CCI + PEA distal part of the sciatic nerve of CCI mice s.c. treated with 30 mg kg<sup>−1</sup> PEA daily for 14 days starting from the surgery. Ovoids are evidenced by arrows. Original magnification 20x.</table>

Mediators of Inflammation

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Figure 7

Figure 7: Palmitoylethanolamide Is a Disease-Modifying Agent in Peripheral Neuropathy: Pain Relief and Neuroprotection Share a PPAR-Alpha-Mediated Mechanism 

Figure 7 | Palmitoylethanolamide Is a Disease-Modifying Agent in Peripheral Neuropathy: Pain Relief and Neuroprotection Share a PPAR-Alpha-Mediated Mechanism 