Chronic Pain Treatment: The Influence of Tricyclic Antidepressants on Serotonin Release and Uptake in Mast Cells
Figure 3
The influence of selected TCAs on the uptake of 5-HT into mast cells. Mast cells were preincubated with different concentrations (10−8–10−4 mol/L) of antidepressants (amitriptyline, doxepin, imipramine, and clomipramine) for 10 min. After that, mast cells were incubated with exogenous 5-HT (250 ng/sample) for the next 30 min. Each point represents mean ± SEM of 5 experiments.
