Evaluation of Clinical and Immunological Responses: A 2-Year Follow-Up Study in Children with Allergic Rhinitis due to House Dust Mite

Table 3

Paired estimated difference between year 2, and 0 (median, CIs and 𝑃-value) and Spearman correlation.

	Paired estimated difference				Correlation
	Median	95% CI*		Sign.^#	𝑅𝑠^†	Sign.
Clinical symptoms
Nose (score from 0–12)	−1.34	−1.86	−0.85	<0.0001	0.56	<0.0001
Eye (score from 0–9)	−0.29	−0.62	−0.05	0.02	0.56	<0.0001
Lung (score from 0–6)	−0.33	−0.58	−0.13	<0.0001	0.61	<0.0001
HDM-specific skin test
Early skin test (HEIC)	0.16	−0.03	0.35	0.09	0.44	0.005
Late skin test (mm^2)	199.85	−12.55	458.2	0.07	0.5	0.001
HDM-specific pro-inflammatory response
Specific IgE (kU/L)	1.95	−0.79	6.45	0.17	0.86	<0.0001
Proliferation (SI)	−0.67	−2.02	0.89	0.39	0.38	0.015
IL-5 (pg/mL)	−132.1	−450.62	69.51	0.19	0.27	0.087
IL-13 (pg/mL)	133.92	−210.18	538.48	0.46	0.36	0.022
IFN-gamma (pg/mL)	−44.84	−82.33	−4.00	0.01	0.35	0.027
HDM-specific regulatory response
CD4^+CD25^hi (% of CD3^+)	0.44	0.3	0.56	<0.0001	0.18	0.27
FoxP3 (relative expression)	−0.12	−0.67	0.41	0.64	0.24	0.13
IL-10 (pg/mL)	−39.34	−67.66	−10.56	0.002	0.357	0.024
TGF-beta (pg/mL)	41.43	0.00	144.01	0.18	0.032	0.84

∗CI: confidence interval Hodges Lehman.
^#𝑃-value, Wilcoxon.
𝑅_𝑠^†: Spearman rank correlation between year 0 and year 2.