Melatonin Improves Outcomes of Heatstroke in Mice by Reducing Brain Inflammation and Oxidative Damage and Multiple Organ Dysfunction

Figure 1

Percent survival values for nonheated mice untreated (A), heated mice treated with vehicle solution (B), heated mice treated with melatonin (0.2 mg/kg) (C), heated mice treated with melatonin (1 mg/kg) (D), and heated mice treated with melatonin (5 mg/kg) (E) 4–96 hours after whole body heating (WBH). Data are expressed as means±S.E.M. for 12 mice per group. ^∗𝑃<0.05compared with nonheated mice untreated mice; ⁺𝑃<0.05compared with heated mice treated with vehicle solution.