Melatonin Improves Outcomes of Heatstroke in Mice by Reducing Brain Inflammation and Oxidative Damage and Multiple Organ Dysfunction

Table 3

Effects of heat exposure on hypothalamic levels of various parameters in different groups of mice.

Treatment groups	TNF-α (pg/g)	IL-1β (pg/g)	IL-10 (pg/g)	MPO activity (pg/wet tissue)
(1) Non-heated mice	10±3	8±2	5±2	51±8
(2) Heated mice treated with vehicle solution	208±18^a	426±51^a	6±3	448±14
(3) Heated mice treated with melatonin 0.2 mg/kg	224±21	453±56	4±2	507±17
(4) Heated mice treated with melatonin 1 mg/kg	88±8^b	190±18^b	212±22^b	144±9^b
(5) Heated mice treated with melatonin 5 mg/kg	9±3^b	8±3^b	256±30^b	51±11^b

Samples were measured 4 hours after whole body heating for non-heated groups. ^aCompared with non-heated groups (𝑃<0.05); ^bCompared with group 2 (𝑃<0.05). Data are means ± S.E.M. of 12 mice per group.