Melatonin Improves Outcomes of Heatstroke in Mice by Reducing Brain Inflammation and Oxidative Damage and Multiple Organ Dysfunction

Table 5

Effect of heat exposure on serum levels of blood urea nitrogen (BUN), creatinine, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphate (AP) in different groups of mice.

Treatment groups	BUN (mmol/L)	Creatinine (mmol/L)	ALT (U/L)	AST (U/L)	AP (U/L)
(1) Non-heated mice	8±1	27±2	35±4	111±8	299±23
(2) Heated mice treated with vehicle solution	23±1^a	75±3^a	129±5^a	508±22^a	533±31^a
(3) Heated mice treated with melatonin 0.2 mg/kg	21±2	69±4	130±6	492±21	505±28
(4) Heated mice treated with melatonin 1 mg/kg	15±2^b	52±2^b	85±3^b	274±16^b	395±19^b
(5) Heated mice treated 5 mg/kg	10±1^b	43±3^b	67±4^b	188±12^b	364±17^b

Samples were measured 4 hours after whole body heating or the equivalent time period for non-heated groups. ^aCompared with non-heated group (𝑃<0.05); ^bCompared with group 2 (𝑃<0.05). Data are means ± S.E.M. of 12 mice per group.