Protective Effects of Polydatin on Septic Lung Injury in Mice via Upregulation of HO-1

Figure 2

Histology changes and edema in the lungs from the treated-mice. Mice were pretreated i.p. with vehicle (PBS) or PD (15, 45, and 100 mg/kg, resp.) in the presence or absence of ZnPP IX (40 mg/kg) 1 h before CLP. The lung tissues were obtained from kill mice 24 h after CLP (a) Hematoxylin and eosin-staining (original magnification, 400x) and (b) total histology scores were determined. (c) The wet/dry ratio of lung tissue was assayed. ^∗𝑃<0.05, ^∗∗𝑃<0.01 versus the CLP group. ^##𝑃<0.01 versus the CLP-PD group.

(a)

(b)

(c)