Conditioned Media from Adipose-Tissue-Derived Mesenchymal Stem Cells Downregulate Degradative Mediators Induced by Interleukin-1β in Osteoarthritic Chondrocytes

Figure 5

Effects of CM on chemokine mRNA expression. mRNA expression was determined by real-time PCR analysis in OA chondrocytes after 24 h of incubation in the presence or absence of IL-1𝛽 and/or CM. Results indicate relative expression with respect to nonstimulated OA chondrocytes. Data represent mean ± S.E.M. of independent cultures with chondrocytes from 4 different donors. ⁺⁺𝑃<0.01 with respect to nonstimulated cells; **𝑃<0.01 with respect to IL-1𝛽.

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