PD-L1 Blockade Attenuated Sepsis-Induced Liver Injury in a Mouse Cecal Ligation and Puncture Model

Figure 6

Anti-PD-L1 antibody altered mRNA expression of IL-6, IL-10, and TNF-α in the liver of septic mice. Mice were administered anti-PD-L1 antibody (50 μg, i.p.). Liver specimens were sampled 24 hours after surgery. ^∗𝑃<0.01 versus Sham, ^∗∗∗𝑃<0.01 versus CLP, ^∗∗𝑃=0.7128 (IL-6), 𝑃=0.8133 (IL-10), and 𝑃=0.1228 (TNF-α) versus CLP. Bars represent the mean ± SD of eight mice for each group.

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