MMP-3 Contributes to Nigrostriatal Dopaminergic Neuronal Loss, BBB Damage, and Neuroinflammation in an MPTP Mouse Model of Parkinson’s Disease
Figure 3
Effects of MMP-3 on motor performance in MPTP-treated mice. (a) After 7 days from MPTP injection, mice were subjected to rotating rod (20 rpm) for 20 min, and falling time was recorded. (b) Next day, mice were placed on an accelerating rotating rod, and the maximum time before the mouse fell from the rod was recorded. Five to six animals were used for each experimental group. Two way ANOVA with Bonferroni post hoc test, fixed mode; (, ), accelerating mode; (, ), and , significantly different from PBS-injected MMP-3+/+ mice; , significantly different from MPTP injected MMP-3+/+ mice.
