Heat Shock Proteins 60 and 70 Specific Proinflammatory and Cytotoxic Response of CD4⁺CD28^null Cells in Chronic Kidney Disease

Table 2

IFN-𝛾, perforin and granzyme B secreted (numbers of spots) from CD4⁺CD28^null cell and CD4⁺CD28⁺ T cells during ELISPOT assay with and without stimulation with PHA (10 µg/mL), HSP60 (5 ng/mL) and HSP70 (5 ng/mL) in CKD subjects.

	CD4^+ Cells	Unstimulated Control	PHA	HSP60	HSP70
IFN-𝛾	CD28^null	51.92±5.9	252.56±24.5	174.32±19.3	125.48±14.3
	CD28^+	16.64±2.4	203.44±31.3	57.12±6.4	54.64±7.7
Perforin	CD28^null	30.84±4.1	119.44±14.7	65.92±9.3	51.4±6.1
	CD28^+	12.36±1.5	98.44±15.5	27.24±4.7	24.08±4.4
Granzyme B	CD28^null	57.28±6.2	197.52±21.8	122.52±15.6	104.56±15.8
	CD28^+	20.8±3.5	171.6±31.3	39.2±5.9	40±7.6