Human Leukocyte Antigen Class II Alleles (DQB1 and DRB1) as Predictors for Response to Interferon Therapy in HCV Genotype 4
Table 4
Frequencies and percentages of linkage between HLA familial alleles in HCV patients and healthy group and in responder and nonresponder patients to combined treatment of interferon and ribavirin.
Haplotypes
HCV patients ()
Healthy controls ()
P value
Responders
Nonresponders
P value
DQB1*02-DQB1*03
15 (24.2%)
32 (56.1%)
0.015†
9 (23.7%)
6 (30%)
0.754
DQB1*02-DQB1*05
3 (4.8%)
10 (17.5%)
0.325
2 (5.3%)
1 (5%)
1.000
DQB1*02-DQB1*06
7 (11.3%)
4 (7%)
0.724
5 (13.2%)
2 (10%)
1.000
DQB1*03-DQB1*05
5 (8.1%)
10 (17.5%)
0.823
4 (10.5%)
1 (5%)
0.650
DQB1*03-DQB1*06
9 (14.5%)
3 (5.3%)
0.212
8 (21.1%)
1 (5%)
0.143
DQB1*05-DQB1*06
2 (3.2%)
4 (7%)
0.417
1 (2.6%)
1 (5%)
1.000
DQB1*02-DRB1*03
11 (17.7%)
2 (3.5%)
0.187
7 (18.4%)
4 (20%)
1.000
DQB1*02-DRB1*07
15 (24.2%)
35 (61.4%)
0.008†
10 (26.3%)
5 (25%)
1.000
DQB1*02-DRB1*13
7 (11.3%)
2 (3.5%)
0.222
6 (15.8%)
1 (5%)
0.403
DQB1*03-DRB1*03
10 (16.2%)
3 (5.3%)
0.250
6 (15.8%)
4 (20%)
0.724
DQB1*03-DRB1*04
11 (17.7%)
12 (21.1%)
0.219
5 (13.2%)
6 (30%)
0.163
DQB1*03-DRB1*07
10 (16.2%)
36 (63.2%)
0.000†
6 (15.8%)
4 (20%)
0.724
DQB1*03-DRB1*13
13 (21%)
1 (1.8%)
0.147
11 (28.9%)
2 (10%)
0.184
DQB1*05-DRB1*01
2 (3.2%)
6 (10.5%)
0.428
2 (5.3%)
0 (0%)
0.540
DQB1*05-DRB1*10
3 (4.8%)
0 (0.0%)
1.000
3 (7.9%)
0 (0%)
0.544
DQB1*06-DRB1*15
9 (14.5%)
4 (7%)
0.324
6 (15.8%)
3 (15%)
1.000
DRB1*03-DRB1*13
2 (3.2%)
3 (5.3%)
0.173
2 (4.9%)
0 (0%)
0.545
DRB1*04-DRB1*11
3 (4.8%)
7 (12.3%)
0.762
0 (0.0%)
3 (14.3%)
0.035#
DRB1*07-DRB1*13
4 (6.5%)
2 (3.5%)
0.071
3 (7.9%)
1 (4.8%)
1.000
DRB1*07-DRB1*15
3 (4.8%)
6 (10.5%)
0.421
1 (2.4%)
2 (9.5%)
0.263
DRB1*13-DRB1*14
2 (3.2%)
0 (0.0%)
0.568
0 (0%)
2 (9.5%)
0.111
DRB1*13-DRB1*15
2 (3.2%)
2 (3.5%)
0.247
2 (4.9%)
0 (0%)
0.545
Significant difference at PC ≤ 0.05 (corrected P after the Bonferroni correction) between responder and nonresponder patients to treatment. †Significant difference at PC ≤ 0.05 (corrected P after the Bonferroni correction) between patients and healthy group. Each patient may have multiple suballeles or none at all, so that totals are not always equal to “.”
