Carrageenan-Induced Colonic Inflammation Is Reduced in Bcl10 Null Mice and Increased in IL-10-Deficient Mice
Figure 2
Carrageenan-induced increases in KC and calprotectin are less in Bcl10 null mice. (a) KC, the mouse homolog of IL-8, increased less in the Bcl10 null mice () than in the wild type () or heterozygous () mice following carrageenan to ~77% of the higher value ( ng/L versus ng/L; ). (b) Fecal calprotectin, an indicator of colonic inflammation, also increased less following carrageenan in the Bcl10 null mice than in the wild type or heterozygous mice, to μg/kg versus μg/kg in the wild type mice (). CGN: carrageenan; KC: keratinocyte chemokine; WT: wild type; het: heterozygous.
