Carrageenan-Induced Colonic Inflammation Is Reduced in Bcl10 Null Mice and Increased in IL-10-Deficient Mice
Figure 3
Serum IL-6 and MCP-1 increase post-carrageenan exposure, and increases are similar in Bcl10 WT, heterozygous, and null mice. Carrageenan exposure produced significant increases in serum levels of IL-6 and MCP-1 in the WT, heterozygous, and null mice (), compared to the unexposed controls. WT, heterozygotes, and null mice serum levels of MCP-1 and IL-6 both increased ~85%. Serum levels of TNF-α, IFNγ, IL-1β, IL-10, IL-12, and IL-23 did not change.
