Carrageenan-Induced Colonic Inflammation Is Reduced in Bcl10 Null Mice and Increased in IL-10-Deficient Mice
Figure 5
Phosphorylation of Bcl10 is absent and of IκBα is reduced in Bcl10 null mice following carrageenan. (a) Phospho(Ser138)-Bcl10 was increased to ~400% of the no carrageenan baseline when the Bcl10 wild type and heterozygous mice were exposed to carrageenan () but not in the Bcl10 null mice. (b) The increase in phospho(Ser32)-IκBα is less in the Bcl10 null mice, compared to the wild type and heterozygous mice (increase of ~37% versus ~91%), but the increase from the baseline no carrageenan value is also significant (). CGN: carrageenan; WT: wild type; Het: heterozygous.
