Figure 1: Serum SDMA concentrations in critically ill patients. (a) At admission to the medical ICU, serum SDMA levels were significantly (, test) elevated in critically ill patients () as compared to healthy controls (). (b) SDMA serum levels at ICU admission were significantly increased in ICU patients with sepsis () compared to patients without sepsis (). (c) SDMA serum levels at ICU admission were significantly increased in ICU patients with higher degree of disease severity, as displayed by the APACHE-II score. (d) In 42 patients, SDMA levels were measured at admission (day 1) and at 1 week (day 7) of ICU therapy. SDMA levels remained stable during the first week of ICU treatment (paired Wilcoxon test).