Regulation and Prognostic Relevance of Symmetric Dimethylarginine Serum Concentrations in Critical Illness and Sepsis
Table 1
Baseline patient characteristics and SDMA serum measurements.
Parameter
All patients
Sepsis
Nonsepsis
value
Number
247
160
87
—
Sex (male/female)
145/102
94/66
51/36
—
Age median (range) [years]
63 (18–90)
64 (20–90)
60 (18–85)
n.s.
APACHE-II score median (range)
17 (2–43)
19 (3–43)
15 (2–33)
0.002
SOFA score median (range)
9 (0–19)
11 (3–19)
7 (0–16)
<0.001
ICU days median (range)
8 (1–137)
10 (1–137)
6 (1–45)
<0.001
Death during ICU (%)
60 (24.3)
45 (28.1)
15 (17.2)
—
Death during follow-up (%)
115 (47.3)
85 (54.1)
30 (34.9)
—
Mechanical ventilation (%)
171 (71.5)
117 (75.5)
54 (64.3)
—
Ventilation time median (range) [h]
126 (0–2966)
181 (0–2966)
63 (0–986)
0.019
Preexisting diabetes (%)
72 (29.1)
45 (28.1)
27 (31.0)
—
BMI median (range) [m²/kg]
25.8 (15.9–86.5)
25.8 (17.1–86.5)
25.4 (15.9–53.3)
n.s.
WBC median (range) [×10³/µL]
12.7 (0.1–149)
13.8 (0.1–149)
11.4 (1.8–29.6)
0.010
CRP median (range) [mg/dL]
103 (5–230)
162 (5–230)
17 (5–230)
<0.001
Procalcitonin median (range) [µg/L]
1.0 (0.05–248)
3.2 (0.1–248)
0.24 (0.05–100)
<0.001
Creatinine median (range) [mg/dL]
1.3 (0.1–21.6)
1.6 (0.1–21.6)
1.0 (0.2–11.5)
n.s.
GFR Cystatin median (range) [mL/min]
33 (3–379)
27 (3–379)
58 (5–379)
0.013
INR median (range)
1.17 (0.9–4.64)
1.18 (0.92–4.64)
1.16 (0.9–4.32)
n.s.
SDMA day 1 median (range) [µmol/L]
0.84 (0.15–4.0)
0.89 (0.19–4.0)
0.67 (0.15–3.86)
0.018
SDMA day 7 median (range) [µmol/L]
0.82 (0.18–3.34)
0.85 (0.18–3.34)
0.81 (0.23–1.50)
n.s.
For quantitative variables, median and range (in parenthesis) are given. Differences between sepsis and nonsepsis patients were tested for significance ( values [ test] are given in the table). APACHE: Acute Physiology and Chronic Health Evaluation; BMI: body mass index; CRP: C-reactive protein; ICU: intensive care unit; INR: international normalized ratio; SDMA: symmetric dimethylarginine; SOFA: sequential organ failure assessment; WBC: white blood cell count.
