Table 1: Baseline patient characteristics and SDMA serum measurements.

ParameterAll patientsSepsisNonsepsis value

Number24716087
Sex (male/female)145/10294/6651/36
Age median (range) [years]63 (18–90)64 (20–90)60 (18–85)n.s.
APACHE-II score median (range)17 (2–43)19 (3–43)15 (2–33)0.002
SOFA score median (range)9 (0–19)11 (3–19)7 (0–16)<0.001
ICU days median (range)8 (1–137)10 (1–137)6 (1–45)<0.001
Death during ICU (%)60 (24.3)45 (28.1)15 (17.2)
Death during follow-up (%)115 (47.3)85 (54.1)30 (34.9)
Mechanical ventilation (%)171 (71.5)117 (75.5)54 (64.3)
Ventilation time median (range) [h]126 (0–2966)181 (0–2966)63 (0–986)0.019
Preexisting diabetes (%)72 (29.1)45 (28.1)27 (31.0)
BMI median (range) [m²/kg]25.8 (15.9–86.5)25.8 (17.1–86.5)25.4 (15.9–53.3)n.s.
WBC median (range) [×10³/µL]12.7 (0.1–149)13.8 (0.1–149)11.4 (1.8–29.6)0.010
CRP median (range) [mg/dL]103 (5–230)162 (5–230)17 (5–230)<0.001
Procalcitonin median (range) [µg/L]1.0 (0.05–248)3.2 (0.1–248)0.24 (0.05–100)<0.001
Creatinine median (range) [mg/dL]1.3 (0.1–21.6)1.6 (0.1–21.6)1.0 (0.2–11.5)n.s.
GFR Cystatin median (range) [mL/min]33 (3–379)27 (3–379)58 (5–379)0.013
INR median (range)1.17 (0.9–4.64)1.18 (0.92–4.64)1.16 (0.9–4.32)n.s.
SDMA day 1 median (range) [µmol/L]0.84 (0.15–4.0)0.89 (0.19–4.0)0.67 (0.15–3.86)0.018
SDMA day 7 median (range) [µmol/L]0.82 (0.18–3.34)0.85 (0.18–3.34)0.81 (0.23–1.50)n.s.

For quantitative variables, median and range (in parenthesis) are given. Differences between sepsis and nonsepsis patients were tested for significance ( values [ test] are given in the table). APACHE: Acute Physiology and Chronic Health Evaluation; BMI: body mass index; CRP: C-reactive protein; ICU: intensive care unit; INR: international normalized ratio; SDMA: symmetric dimethylarginine; SOFA: sequential organ failure assessment; WBC: white blood cell count.