Regulation and Prognostic Relevance of Symmetric Dimethylarginine Serum Concentrations in Critical Illness and Sepsis

Table 4

Uni- and multivariate Cox regression analyses for SDMA levels at admission to predict ICU mortality.

Parameter	Unadjusted HR (95%-CI)	𝑃 value	Adjusted HR (95%-CI)	𝑃 value
SDMA	1.349 (1.059–1.719)	0.015	1.379 (1.012–1.879)	0.042
Protein	0.961 (0.939–0.984)	0.001	0.966 (0.940–0.993)	0.012
INR	1.890 (1.370–2.607)	<0.001	1.537 (1.004–2.354)	0.048
Lactate	1.169 (1.085–1.260)	<0.001	1.142 (1.058–1.231)	0.001
Creatinine	1.026 (0.937–1.123)	NS	—	NS
White blood cell count	0.986 (0.955–1.018)	NS	—	NS
C-reactive protein	1.0 (0.997–1.003)	NS	—	NS