Metformin Inhibits Expression and Secretion of PEDF in Adipocyte and Hepatocyte via Promoting AMPK Phosphorylation

Table 2

Characteristics of the animal models.

	NC group (𝑛=6)	HF group (𝑛=6)	MET group (𝑛=6)
Weight at baseline (g)	218.75±16.27	219.60±13.78	219.60±13.78
Weight at the end (g)	458.50±51.50	573.30±44.57^∗	524.2±17.2^∗
FPG (mmol/L)	5.40±0.27	6.02±0.29^∗	5.65±0.42
Fins (mIU/L)	10.98±7.20	33.07±12.67^∗	12.35±7.90^#
TC (mmol/L)	1.26±0.19	1.48±0.15	1.47±0.22
TG (mmol/L)	0.57±0.16	0.67±0.24	0.31±0.07^∗#
LDL-c (mmol/L)	0.35±0.10	0.48±0.11^∗	0.52±0.08^∗
HDL-c (mmol/L)	1.11±0.20	0.97±0.17	1.05±0.12
GIR (μmol⋅kg^−1⋅min^−1)	8.63±0.96	3.65±0.68^∗	7.99±0.92^#
PEDF (μg/mL)	1.77±0.14	2.16±0.09^∗	1.69±0.24^#

Data are presented as mean ± SD and analyzed by one-way ANOVA with the Games Howell test for post hoc analysis. FPG: fasting plasma glucose; Fins: fasting serum insulin; TC: total cholesterol; TG: triglycerides; LDL-c: low-density lipoprotein cholesterol; HDL-c: high-density lipoprotein cholesterol; PEDF: pigment epithelium-derived factor; GIR: glucose infusion rate; NC: normal control; HF: high fat; MET: metformin. ^∗𝑃<0.05, compared with NC group; ^#𝑃<0.05, compared with HF group.