Subclinical Cardiovascular System Changes in Obese Patients with Juvenile Idiopathic Arthritis
Table 2
Traditional cardiovascular risk factors, selected inflammatory markers, and ultrasonographic evaluation of cardiovascular system in the juvenile idiopathic arthritis (JIA) patients and the control group.
JIA patients ( = 58)
Control group ( = 36)
value
Traditional risk factors
Age, years
13.0 (11.0–15.0)
13.4 (12–15)
0.37
BMI, kg/m2
20.6 (16.8–22.2)
19.4 (17.3–20.6)
0.15
BMI-SDS
0.3 (0.0–0.8)
0.1 (−0.5–0.5)
0.03
SBP, mm Hg
117 (102–127)
112 (103–117)
0.02
DBP, mm Hg
67 (64–75)
64 (57–69)
0.03
Total cholesterol, mmol/L
4 (3.6–4.6)
4 (3.5–4.4)
0.60
LDL-cholesterol, mmol/L
2.1 (1.8–2.5)
2 (1.8–2.4)
0.63
HDL-cholesterol, mmol/L
1.4 (1.2–1.6)
1.4 (1.2–1.7)
0.40
Triglycerides, mmol/L
0.7 (0.6–1)
0.7 (0.6–0.9)
0.74
Glucose, mmol/L
4.8 (4.6–5.1)
4.8 (4.6–5.0)
0.75
Insulin, mU/mL
7.5 (4.1–11.5)
6.6 (4.0–8.8)
0.19
HOMA index
1.5 (0.9–2.4)
1.4 (0.8–1.9)
0.19
Inflammatory markers
hsCRP, mg/L
1.07 (0.16–3.84)
0.04 (0.01–0.20)
<0.001
Il-6, pg/ml
2.3 (0.5–6.6)
0.2 (0.2–0.8)
<0.001
TNFα, pg/ml
2.8 (1.0–32)
0.7 (0.7–0.72)
<0.001
Adiponectin, g/mL
11.3 (8.0–14.0)
12.5 (8.0–16.0)
0.510
Ultrasonographic studies
Brachial artery, mm
3.7 (3.3–4.4)
3.6 (3.2–4.2)
0.560
FMD, %
7.8 (5.1–9.1)
11.1 (9.2–12.6)
<0.001
IMT, mm
0.50 (0.44–0.54)
0.42 (0.39–0.45)
<0.001
LVMi, g/m2.7
27.6 (24.5–29.5)
22.9 (19.2–28.3)
=0.020
Values are presented as median (interquartile range), SBP: systolic blood pressure, DBP: diastolic blood pressure, HOMA index: index of insulin resistance, FMD: flow mediated dilatation of the right brachial artery, IMT: intima-media thickness of the common carotid arteries, and LVMi: indexed left ventricle mass. Mann-Whitney test.
