Subclinical Cardiovascular System Changes in Obese Patients with Juvenile Idiopathic Arthritis
Table 3
Traditional cardiovascular risk factors, selected inflammatory markers, and ultrasonographic evaluation of cardiovascular system in nonobese and obese juvenile idiopathic arthritis (JIA) patients.
JIA patients obese ( = 13)
JIA patients nonobese ( = 45)
Control group ( = 36)
value
Traditional risk factors
Age, years
13.0 (7.5–15)
13.0 (11–15.5)
13.4 (12–15)
0.580
BMI, kg/m2
24.0 (21–29)†‡
19.0 (16–21)
19.4 (17.3–20.6)
<0.001
BMI-SDS
3.0 (1.7–4.2)†‡
0.06 (−0.2–0.4)
0.12 (−0.5–0.5)
<0.001
SBP, mm Hg
127 (113–139)†
117 (101–124)
112 (103–117)
0.020
DBP, mm Hg
69 (58–80)
67 (64–75)
64 (57–69)
0.130
Total cholesterol, mmol/L
4.7 (4.3–5.0)†‡
3.9 (3.6–4.3)
4 (3.6–4.4)
0.010
LDL-cholesterol, mmol/L
2.4 (1.8–2.6)
2.0 (1.7–2.7)
2.0 (1.8–2.4)
0.570
HDL-cholesterol, mmol/l
1.2 (0.9–1.7)
1.5 (1.3–1.6)
1.6 (1.2–1.7)
0.160
Triglycerides, mmol/L
1.3 (0.7–1.5)‡
0.7 (0.6–0.9)
0.7 (0.6–0.9)
0.040
Glucose, mmol/L
4.8 (4.5–5.1)
4.8 (4.7–5.1)
4.8 (4.6–5.0)
0.690
Insulin, mU/mL
12.4 (11.0–14.3)†‡
6.8 (3.8–8.9)
6.6 (4.0–8.8)
<0.001
HOMA index
2.7 (2.1–3.1)†‡
1.5 (0.8–2.0)
1.45 (0.8–1.9)
=0.001
Inflammatory markers
hsCRP, mg/L
5.3 (1.4–7.4)†‡
0.6 (0.1–1.6)†
0.04 (0.01–0.2)
<0.001
Il-6, pg/mL
8.6 (4.4–13.2)†‡
1.4 (0.4–4.2)†
0.2 (0.2–0.8)
<0.001
TNF, pg/mL
3.3 (1–32)†
2.6 (1–32)†
0.7 (0.7–0.72)
<0.001
Adiponectin, g/mL
12 (11.5–13.6)
10.5 (6.9–15.6)
12.5 (8.0–16.0)
=0.570
Ultrasonographic studies
Brachial artery, mm
3.8 (3.8–3.9)
3.6 (3.3–4.2)
3.6 (3.2–4.2)
=0.520
FMD, %
4.8 (2.7–5.7)†‡
8.2 (6.5–9.6)†
11.1 (9.2–12.6)
<0.001
IMT, mm
0.54 (0.51–0.56)†‡
0.48 (0.43–0.53)†
0.42 (0.39–0.45)
<0.001
LVMi, g/m2.7
30.2 (27–45)†
26.8 (21.8–28.5)
22.9 (19.2–28.3)
=0.003
Values are presented as median (interquartile range), obese: group of patients with recognized overweight and obesity, SBP: systolic blood pressure, DBP: diastolic blood pressure, HOMA index: index of insulin resistance, FMD: flow mediated dilatation of the right brachial artery, IMT: intima-media thickness of the common carotid arteries, and LVMi: indexed left ventricle mass. ANOVA Kruskal-Wallis test. in comparison to the control group in post hoc test. obese versus nonobese JIA groups in post hoc test.
