How Histopathology Can Contribute to an Understanding of Defense Mechanisms against Cryptococci
Figure 4
(a) Numerous and irregular-sized yeasts were diffusely observed in the pulmonary sections of cryptococcosis in homozygous (nu/nu) nude mice, but no multinucleated giant cell (MGC) was observed (periodic acid Schiff reaction, original magnification ×200). (b) MGCs with a well-developed and dense eosinophilic cytoplasm containing the yeasts were observed in the pulmonary sections of cryptococcosis in heterozygous nude mice (periodic acid Schiff reaction, original magnification ×200).
