How Histopathology Can Contribute to an Understanding of Defense Mechanisms against Cryptococci
Figure 6
(a) Pulmonary sections of mice infected with C. gattii R265 exhibited eccentric pulmonary enlargement (periodic acid Schiff (PAS) reaction, ×200). (b) Pulmonary sections of mice infected with C. gattii R265 showed multinucleated giant cells with a foamy cytoplasm, and a small number of nuclei that were loosely aggregated (PAS reaction, ×1000). (c) Pulmonary sections of mice infected with C. neoformans H99 showed multiple well-demarcated nodular lesions, but no alveolar expansion was observed (PAS reaction, ×200). (d) Pulmonary sections of mice infected with C. neoformans H99 showed multinucleated giant cells with a well-developed and dense eosinophilic cytoplasm and a large number of nuclei (PAS reaction, ×1000).
